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This Week in Microbiology Capturing Shigella With Filopodia

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Hosts: Michael Schmidt, Ph.D., Michele Swanson, Ph.D., Petra Levin, Ph.D., Vincent Racaniello, Ph.D.

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Summary

Shigella infection is facilitated by interaction of human enteric 伪-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to 尾-lactams by preventing dysregulation of amino acid and nucleotide metabolism

Published on Feb. 28, 2025

Episode Summary

TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism

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Capturing Shigella With Filopodia
This electron micrograph shows exaggerated filopodia with club-like shape induced by formin mDia2 in cultured cells. These filopodia are filled with bundled actin filaments which were born in and converged from the lamellipodial network. Image by: Lubov Czech, Tatyana Svitkina, and Changsong Yang - PLoS Biology Featured Image, Vol. 5(11) November 2007. http://biology.plosjournals.org/perlserv/?request=cover-legend&volume=5&issue=11

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