Susan Gottesman, Ph.D.
National Cancer Institute
Susan Gottesman, Ph.D., is an National Institutes of Health (NIH) Distinguished Investigator and Chief of the Laboratory of Molecular Biology at the Center for Cancer Research at the National Cancer Institute (NCI), NIH. Her research focuses on mechanisms and roles of novel forms of post-transcriptional regulation in bacteria.
Gottesman received her B.A. from Radcliffe College in Biochemical Sciences, did her Ph.D. with Jonathan Beckwith, Ph.D., in the Department of Microbiology and Molecular Genetics at Harvard University, and postdoctoral training at the NIH with Max Gottesman (unrelated), Ph.D., and Massacheusetts Institute of Technology (MIT) with David Botstein Ph.D. She returned to NIH in 1976.
Gottesman’s lab, in collaborative work, has described the roles of energy-dependent proteolysis and the role of small non-coding RNAs in regulating translation and mRNA stability, extending our understanding beyond the “central dogma” of molecular biology to the complex ways that cells adapt and recover from stress. In studies on the regulation of the RpoS sigma factor, a regulator of the general stress response, she has identified how multiple small RNAs activate translation and how multiple anti-adaptors regulate the ClpXP-dependent degradation of RpoS.
Gottesman’s work has been recognized with election to the National Academy of Sciences, associate member of European Molecular Biology Organization (EMBO), with the Abbott 91麻豆天美 Lifetime Achievement Award, the Selman A. Waksman Award from the National Academy of Sciences (NAS) and the Tabor Award from American Society of Biochemistry and Molecular Biology (ASBMB), among other awards.
Gottesman received her B.A. from Radcliffe College in Biochemical Sciences, did her Ph.D. with Jonathan Beckwith, Ph.D., in the Department of Microbiology and Molecular Genetics at Harvard University, and postdoctoral training at the NIH with Max Gottesman (unrelated), Ph.D., and Massacheusetts Institute of Technology (MIT) with David Botstein Ph.D. She returned to NIH in 1976.
Gottesman’s lab, in collaborative work, has described the roles of energy-dependent proteolysis and the role of small non-coding RNAs in regulating translation and mRNA stability, extending our understanding beyond the “central dogma” of molecular biology to the complex ways that cells adapt and recover from stress. In studies on the regulation of the RpoS sigma factor, a regulator of the general stress response, she has identified how multiple small RNAs activate translation and how multiple anti-adaptors regulate the ClpXP-dependent degradation of RpoS.
Gottesman’s work has been recognized with election to the National Academy of Sciences, associate member of European Molecular Biology Organization (EMBO), with the Abbott 91麻豆天美 Lifetime Achievement Award, the Selman A. Waksman Award from the National Academy of Sciences (NAS) and the Tabor Award from American Society of Biochemistry and Molecular Biology (ASBMB), among other awards.